Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke.

Erdő Franciska and Buhrle C and Blunk J and Hoehn M and Xia Y and Fleischmann B and Focking M and Kustermann E and Kolossov E and Hescheler J and Hossmann KA and Trapp T: Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 23 (7). pp. 780-785. ISSN 0271-678X (2003)

Text
erdo-et-al-2003-host-dependent-tumorigenesis-of-embryonic-stem-cell-transplantation-in-experimental-stroke.pdf - NEM RÉSZLETEZETT
Download (1MB)

Item Type:

Article

Creators:

Creators	ORCID	MTMT szerző azonosító
Erdő Franciska		10044620
Buhrle C
Blunk J
Hoehn M
Xia Y
Fleischmann B
Focking M
Kustermann E
Kolossov E
Hescheler J
Hossmann KA
Trapp T

Abstract:

The therapeutical potential of transplantation of undifferentiated and predifferentiated murine embryonic stem cells for the regeneration of the injured brain was investigated in two rodent stroke models. Undifferentiated embryonic stem cells xenotransplanted into the rat brain at the hemisphere opposite to the ischemic injury migrated along the corpus callosum towards the damaged tissue and differentiated into neurons in the border zone of the lesion. In the homologous mouse brain, the same murine embryonic stem cells did not migrate, but produced highly malignant teratocarcinomas at the site of implantation, independent of whether they were predifferentiated in vitro to neural progenitor cells. The authors demonstrated a hitherto unrecognized inverse outcome after xenotransplantation and homologous transplantation of embryonic stem cells, which raises concerns about safety provisions when the therapeutical potential of human embryonic stem cells is tested in preclinical animal models.

Journal or Publication Title:

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Date:

2003

Volume:

Number:

Page Range:

pp. 780-785

ISSN:

0271-678X

Institution:

Pázmány Péter Katolikus Egyetem