Talampanel improves the functional deficit after transient focal cerebral ischemia in rats. A 30-day follow up study.

Erdő Franciska and Berzsenyi P and Nemet L and Andrasi F: Talampanel improves the functional deficit after transient focal cerebral ischemia in rats. A 30-day follow up study.
BRAIN RESEARCH BULLETIN, 68 (4). pp. 269-276. ISSN 0361-9230 (2006)

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Item Type: Article
Creators:
CreatorsORCIDMTMT szerző azonosító
Erdő Franciska10044620
Berzsenyi P
Nemet L
Andrasi F
Abstract: The neuroprotective effect of talampanel, a negative allosteric modulator of alpha-amino-3-hydroxy-methyl-4-isoxazolyl-propionic acid (AMPA) receptors has been described previously. However, in these studies the histological changes and not the functional consequences of the brain damage were evaluated. The aim of present investigation was to analyze the sensorimotor function after stroke and to test the influence of talampanel (GYKI-53773, LY-300164) by 30-day monitoring in rats. After 1h middle cerebral artery occlusion (MCAO) general 'well-being', neurological status, spontaneous motor activity, rotation, motor coordination, balancing, muscle strength and reaction time were followed for 1 month. Talampanel (6 x 10 mg/kg i.p. given on the day of stroke) improved the motor coordination in rotarod (p < 0.01) and beam walking (p < 0.01) tests, reduced the number of stroke-induced rotations (p < 0.05), shortened the reflex time on the forelimb contralateral to brain ischemia and improved the survival rate comparing with vehicle treated control. After stroke, serious sensorimotor deficits appeared in rats but they showed partial spontaneous recovery after 30 days. Talampanel treatment enhanced the rate of functional improvement without changing the morphology at the end of the experiment. Our results indicate that modulation of AMPA receptors by talampanel can be a promising therapeutic approach to the treatment of stroke.
Journal or Publication Title: BRAIN RESEARCH BULLETIN
Date: 2006
Volume: 68
Number: 4
Page Range: pp. 269-276
ISSN: 0361-9230
Institution: Pázmány Péter Katolikus Egyetem
Kar: Információs Technológiai Kar (1998-2013.06.)
Nyelv: angol
MTMT rekordazonosító: 2802857
DOI azonosító: 10.1016/j.brainresbull.2005.08.018
Scopus azonosító: 29244455020
WoS azonosító: 000234656200009
Date Deposited: 2025. Mar. 07. 12:04
Last Modified: 2025. Mar. 07. 12:04
URI: https://publikacio.ppke.hu/id/eprint/2379

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