ELM—the Eukaryotic Linear Motif resource—2024 update

Kumar Manjeet and Michael Sushama and Alvarado-Valverde Jesús and Zeke András and Lazar Tamas and Glavina Juliana and Nagy-Kanta Eszter and Donagh Juan Mac and Kálmán Zsófia Etelka and Pascarelli Stefano and Palopoli Nicolas and Dobson László and Suarez Carmen Florencia and Van Roey Kim and Krystkowiak Izabella and Griffin Juan Esteban and Nagpal Anurag and Bhardwaj Rajesh and Diella Francesca and Mészáros Bálint and Dean Kellie and Davey Norman E and Pancsa Rita and Chemes Lucía B and Gibson Toby J: ELM—the Eukaryotic Linear Motif resource—2024 update.
NUCLEIC ACIDS RESEARCH, 52 (D1). D442-D455. ISSN 0305-1048 (2024)

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Article

Creators:

Creators	ORCID	MTMT szerző azonosító
Kumar Manjeet	0000-0002-7146-289X
Michael Sushama	0000-0001-8801-3196
Alvarado-Valverde Jesús	0000-0003-0752-1151
Zeke András		10020466
Lazar Tamas	0000-0001-7496-6711
Glavina Juliana	0000-0001-6336-1290
Nagy-Kanta Eszter	0009-0003-1322-2008	10065218
Donagh Juan Mac	0000-0001-6934-0896
Kálmán Zsófia Etelka		10065249
Pascarelli Stefano	0000-0002-5529-3774
Palopoli Nicolas	0000-0001-7925-6436
Dobson László	0000-0003-2765-3872	10050230
Suarez Carmen Florencia	0000-0003-3783-2241
Van Roey Kim
Krystkowiak Izabella	0000-0002-8863-7086
Griffin Juan Esteban	0009-0000-1378-7066
Nagpal Anurag	0000-0002-3087-3406
Bhardwaj Rajesh	0000-0002-5599-487X
Diella Francesca
Mészáros Bálint	0000-0003-0919-4449
Dean Kellie	0000-0002-3213-8181
Davey Norman E	0000-0001-6988-4850
Pancsa Rita	0000-0003-0849-9312	10058394
Chemes Lucía B	0000-0003-0192-9906
Gibson Toby J	0000-0003-0657-5166

Abstract:

Short Linear Motifs (SLiMs) are the smallest structural and functional components of modular eukaryotic proteins. They are also the most abundant, especially when considering post-translational modifications. As well as being found throughout the cell as part of regulatory processes, SLiMs are extensively mimicked by intracellular pathogens. At the heart of the Eukaryotic Linear Motif (ELM) Resource is a representative (not comprehensive) database. The ELM entries are created by a growing community of skilled annotators and provide an introduction to linear motif functionality for biomedical researchers. The 2024 ELM update includes 346 novel motif instances in areas ranging from innate immunity to both protein and RNA degradation systems. In total, 39 classes of newly annotated motifs have been added, and another 17 existing entries have been updated in the database. The 2024 ELM release now includes 356 motif classes incorporating 4283 individual motif instances manually curated from 4274 scientific publications and including >700 links to experimentally determined 3D structures. In a recent development, the InterPro protein module resource now also includes ELM data. ELM is available at: http://elm.eu.org.

Journal or Publication Title:

NUCLEIC ACIDS RESEARCH

Date:

2024

Volume:

Number:

Page Range:

D442-D455

ISSN:

0305-1048

Institution:

Pázmány Péter Katolikus Egyetem