Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention

Than Nándor Gábor and Romero Roberto and Posta Máté and Györffy Dániel and Szalai Gábor and Rossi Simona W and Szilágyi András and Hupuczi Petronella and Nagy Sándor and Török Olga and Tarca Adi L and Erez Offer and Ács Nándor and Papp Zoltán: Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 161. ISSN 0165-0378 (2024)

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Item Type:

Article

Creators:

Creators	ORCID	MTMT szerző azonosító
Than Nándor Gábor		10011696
Romero Roberto
Posta Máté		10082656
Györffy Dániel		10019484
Szalai Gábor		10025710
Rossi Simona W
Szilágyi András	0000-0002-1773-6861	10010376
Hupuczi Petronella		10012513
Nagy Sándor		10034624
Török Olga		10039073
Tarca Adi L
Erez Offer
Ács Nándor	0000-0002-1919-1869	10013998
Papp Zoltán		1373182

Abstract:

The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of the pathologic processes leading to pre-eclampsia. The current gaps in knowledge on the heterogeneous molecular pathways of this syndrome and the lack of adequate, specific diagnostic methods are major obstacles to early screening and tailored preventive strategies. The development of novel diagnostic tools for detecting the activation of the identified disease pathways would enable early, accurate screening and personalized preventive therapies. We implemented a holistic approach that includes the utilization of different proteomic profiling methods of maternal plasma samples collected from various ethnic populations and the application of systems biology analysis to plasma proteomic, maternal demographic, clinical characteristic, and placental histopathologic data. This approach enabled the identification of four molecular subclasses of pre-eclampsia in which distinct and shared disease mechanisms are activated. The current review summarizes the results and conclusions from these studies and the research and clinical implications of our findings.

Journal or Publication Title:

JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Date:

2024

Volume:

161

ISSN:

0165-0378

Institution:

Pázmány Péter Katolikus Egyetem

Kar:

Információs Technológiai és Bionikai Kar (2013.07.-)