Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms

Chakravarty Suchana; Hong Christian I.; Csikász-Nagy Attila: Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS, 9 (1). ISSN 2056-7189 (2023)

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Folyóiratcikk

Szerző azonosítók:

Név	ORCID	MTMT szerző azonosító
Chakravarty Suchana		10065228
Hong Christian I.
Csikász-Nagy Attila	0000-0002-2919-5601	10012379

Absztrakt (kivonat):

Temperature compensation and robustness to biological noise are two key characteristics of the circadian clock. These features allow the circadian pacemaker to maintain a steady oscillation in a wide range of environmental conditions. The presence of a time-delayed negative feedback loop in the regulatory network generates autonomous circadian oscillations in eukaryotic systems. In comparison, the circadian clock of cyanobacteria is controlled by a strong positive feedback loop. Positive feedback loops with substrate depletion can also generate oscillations, inspiring other circadian clock models. What makes a circadian oscillatory network robust to extrinsic noise is unclear. We investigated four basic circadian oscillators with negative, positive, and combinations of positive and negative feedback loops to explore network features necessary for circadian clock resilience. We discovered that the negative feedback loop system performs the best in compensating temperature changes. We also show that a positive feedback loop can reduce extrinsic noise in periods of circadian oscillators, while intrinsic noise is reduced by negative feedback loops.

Folyóirat/kiadvány címe:

NPJ SYSTEMS BIOLOGY AND APPLICATIONS

Évszám:

2023

Kötet:

Szám:

ISSN:

2056-7189

Intézmény:

Pázmány Péter Katolikus Egyetem

Kar:

Információs Technológiai és Bionikai Kar (2013.07.-)