Erdő Franciska; Berzsenyi P; Andrasi F:
The AMPA-antagonist talampanel is neuroprotective in rodent models of focal cerebral ischemia.
BRAIN RESEARCH BULLETIN, 66 (1).
pp. 43-49.
ISSN 0361-9230
(2005)
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| Absztrakt (kivonat): | Cerebroprotection after administration of glutamate receptor antagonists has been well documented. The present study is intended to determine whether the non-competitive alpha-amino-3-hydroxy-methyl-4-isoxazolyl-propionic acid (AMPA) receptor antagonist talampanel, known as antiepileptic drug, has neuroprotective effects in stroke models in rodents. The infarct size was measured in three models of stroke by 2,3,5-triphenyltetrazolium chloride staining. Therapeutic time window was also examined in rats subjected to 1h middle cerebral artery occlusion. The degree of neuroprotection was tested in mice, using 1.5, 2 h or permanent middle cerebral artery occlusions. Effect on photochemically induced thrombosis was investigated in rats applying 30 min time window after brain irradiation. Talampanel reduced the infarct size by 47.3% (p<0.01) after a 30 min delay and 48.5% (p<0.01) after 2 h delay following middle cerebral artery occlusion in rats. In mice, talampanel reduced the extension of the infarcted tissue at the levels of striatum and hippocampus by 44.5% (p<0.05) and 39.3% (p<0.01) after 1.5 h transient ischemia and still caused 37.0% (p<0.05) and 37.0% (p<0.05) inhibitions when 2 h occlusion was applied. In photothrombosis talampanel showed a 40.1% (p<0.05) inhibition. Protective actions of talampanel in various stroke models, in rats and mice, suggest a possible therapeutic role of the compound in stroke patients. | ||||||||||||
| Folyóirat/kiadvány címe: | BRAIN RESEARCH BULLETIN | ||||||||||||
| Évszám: | 2005 | ||||||||||||
| Kötet: | 66 | ||||||||||||
| Szám: | 1 | ||||||||||||
| Oldalak: | pp. 43-49 | ||||||||||||
| ISSN: | 0361-9230 | ||||||||||||
| Intézmény: | Pázmány Péter Katolikus Egyetem | ||||||||||||
| Kar: | Információs Technológiai Kar (1998-2013.06.) | ||||||||||||
| Nyelv: | angol | ||||||||||||
| MTMT rekordazonosító: | 2802858 | ||||||||||||
| DOI azonosító: | 10.1016/j.brainresbull.2005.03.012 | ||||||||||||
| Scopus azonosító: | 19544365764 | ||||||||||||
| WoS azonosító: | 000229852400006 | ||||||||||||
| Dátum: | 2025. Már. 07. 11:55 | ||||||||||||
| Utolsó módosítás: | 2025. Már. 07. 11:55 | ||||||||||||
| URI: | https://publikacio.ppke.hu/id/eprint/2378 |
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