A Kinetic Finite Volume Discretization of the Multidimensional PIDE Model for Gene Regulatory Networks

Vághy Mihály András; Otero-Muras I; Pájaro M; Szederkényi Gábor: A Kinetic Finite Volume Discretization of the Multidimensional PIDE Model for Gene Regulatory Networks.
BULLETIN OF MATHEMATICAL BIOLOGY, 86 (2). ISSN 0092-8240 (2024)

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Szerző azonosítók:

Név	ORCID	MTMT szerző azonosító
Vághy Mihály András		10080211
Otero-Muras I
Pájaro M
Szederkényi Gábor	0000-0003-4199-6089	10000614

Absztrakt (kivonat):

In this paper, a finite volume discretization scheme for partial integro-differential equations (PIDEs) describing the temporal evolution of protein distribution in gene regulatory networks is proposed. It is shown that the obtained set of ODEs can be formally represented as a compartmental kinetic system with a strongly connected reaction graph. This allows the application of the theory of nonnegative and compartmental systems for the qualitative analysis of the approximating dynamics. In this framework, it is straightforward to show the existence, uniqueness and stability of equilibria. Moreover, the computation of the stationary probability distribution can be traced back to the solution of linear equations. The discretization scheme is presented for one and multiple dimensional models separately. Illustrative computational examples show the precision of the approach, and good agreement with previous results in the literature.

Folyóirat címe:

BULLETIN OF MATHEMATICAL BIOLOGY

Megjelenés éve:

2024

Kötet:

Szám:

ISSN:

0092-8240

Intézmény:

Pázmány Péter Katolikus Egyetem

Kar:

Információs Technológiai és Bionikai Kar (2013.07.-)