Mathematical modeling of transdermal delivery of topical drug formulations in a dynamic microfluidic diffusion chamber in health and disease

Szederkényi Gábor; Kocsis Dorottya; Vághy Mihály András; Czárán Domonkos Tamás; Sasvári Péter; Lengyel Miléna; Naszlady Márton Bese; Kreis F; Antal István; Csépányi-Kömi Roland; Erdő Franciska: Mathematical modeling of transdermal delivery of topical drug formulations in a dynamic microfluidic diffusion chamber in health and disease.
PLOS ONE, 19 (4). ISSN 1932-6203 (2024)

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Folyóiratcikk

Szerző azonosítók:

Név	ORCID	MTMT szerző azonosító
Szederkényi Gábor	0000-0003-4199-6089	10000614
Kocsis Dorottya		10080212
Vághy Mihály András		10080211
Czárán Domonkos Tamás		10085536
Sasvári Péter		10085543
Lengyel Miléna	0000-0001-8865-054X	10020628
Naszlady Márton Bese		10084103
Kreis F
Antal István	0000-0002-5434-201X	10020626
Csépányi-Kömi Roland	0000-0001-6825-7142	10023793
Erdő Franciska		10044620

Absztrakt (kivonat):

Mathematical models of epidermal and dermal transport are essential for optimization and development of products for percutaneous delivery both for local and systemic indication and for evaluation of dermal exposure to chemicals for assessing their toxicity. These models often help directly by providing information on the rate of drug penetration through the skin and thus on the dermal or systemic concentration of drugs which is the base of their pharmacological effect. The simulations are also helpful in analyzing experimental data, reducing the number of experiments and translating the in vitro investigations to an in-vivo setting. In this study skin penetration of topically administered caffeine cream was investigated in a skin-on-a-chip microfluidic diffusion chamber at room temperature and at 32̊C. Also the transdermal penetration of caffeine in healthy and diseased conditions was compared in mouse skins from intact, psoriatic and allergic animals. In the last experimental setup dexamethasone, indomethacin, piroxicam and diclofenac were examined as a cream formulation for absorption across the dermal barrier. All the measured data were used for making mathematical simulation in a three-compartmental model. The calculated and measured results showed a good match, which findings indicate that our mathematical model might be applied for prediction of drug delivery through the skin under different circumstances and for various drugs in the novel, miniaturized diffusion chamber. © 2024 Szederkényi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License,

Folyóirat címe:

PLOS ONE

Megjelenés éve:

2024

Kötet:

Szám:

ISSN:

1932-6203

Intézmény:

Pázmány Péter Katolikus Egyetem

Kar:

Információs Technológiai és Bionikai Kar (2013.07.-)