Moculus: an immersive virtual reality system for mice incorporating stereo vision

Sulcz-Judák Linda; Dobos Gergely; Ócsai Katalin; Báthory Eszter; Szebik Huba; Tarján Balázs; Maák Pál; Szadai Zoltán; Takács István Márton; Chiovini Balázs; Lőrincz Tibor; Szepesi Áron; Roska Botond; Szalay Gergely; Rózsa J. Balázs: Moculus: an immersive virtual reality system for mice incorporating stereo vision.
NATURE METHODS, 22. pp. 386-398. ISSN 1548-7091 (2025)

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Folyóiratcikk

Szerző azonosítók:

Név	ORCID	MTMT szerző azonosító
Sulcz-Judák Linda		10030166
Dobos Gergely
Ócsai Katalin		10099458
Báthory Eszter
Szebik Huba		10076338
Tarján Balázs	0009-0002-7958-7133	10085181
Maák Pál		10011238
Szadai Zoltán		10049964
Takács István Márton	0000-0003-2027-2698	10058704
Chiovini Balázs		10017949
Lőrincz Tibor		10063614
Szepesi Áron		10035822
Roska Botond		10079728
Szalay Gergely		10054116
Rózsa J. Balázs	0000-0003-1427-7003	10012926

Absztrakt (kivonat):

Due to technical roadblocks, it is unclear how visual circuits represent multiple features or how behaviorally relevant representations are selected for long-term memory. Here we developed Moculus, a head-mounted virtual reality platform for mice that covers the entire visual field, and allows binocular depth perception and full visual immersion. This controllable environment, with three-dimensional (3D) corridors and 3D objects, in combination with 3D acousto-optical imaging, affords rapid visual learning and the uncovering of circuit substrates in one measurement session. Both the control and reinforcement-associated visual cue coding neuronal assemblies are transiently expanded by reinforcement feedback to near-saturation levels. This increases computational capability and allows competition among assemblies that encode behaviorally relevant information. The coding assemblies form partially orthogonal and overlapping clusters centered around hub cells with higher and earlier ramp-like responses, as well as locally increased functional connectivity.

Folyóirat címe:

NATURE METHODS

Megjelenés éve:

2025

Kötet:

Oldalak:

pp. 386-398

ISSN:

1548-7091

Intézmény:

Pázmány Péter Katolikus Egyetem

Kar: