A Flexible, Implantable, Bioelectronic Electroporation Device for Targeted Ablation of Seizure Foci in the Mouse Brain

Matta Rita; Balogh-Lantos Zsófia; Fekete Zoltán; Baca Martin; Kaszás Attila; Moreau David; O’Connor Rodney P.: A Flexible, Implantable, Bioelectronic Electroporation Device for Targeted Ablation of Seizure Foci in the Mouse Brain.
SENSORS, 25 (1). ISSN 1424-8220 (2025)

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Folyóiratcikk

Szerző azonosítók:

Név	ORCID	MTMT szerző azonosító
Matta Rita
Balogh-Lantos Zsófia		10082493
Fekete Zoltán	0000-0002-6718-4022	10023418
Baca Martin
Kaszás Attila		227
Moreau David
O’Connor Rodney P.

Absztrakt (kivonat):

The primary method of treatment for patients suffering from drug-resistant focal-onset epilepsy is resective surgery, which adversely impacts neurocognitive function. Radio frequency (RF) ablation and laser ablation are the methods with the most promise, achieving seizure-free rates similar to resection but with less negative impact on neurocognitive function. However, there remains a number of concerns and open technical questions about these two methods of thermal ablation, with the primary ones: (1) heating; (2) hemorrhage and bleeding; and (3) poor directionality. Irreversible electroporation (IRE) is a proven method of focal ablation, which circumvents all three of the primary concerns regarding focal RF and laser ablation. Here, we demonstrate the in vivo application of a flexible implant with organic electrodes for focal ablation of epilepsy foci using high-frequency IRE (H-FIRE) in mice. Our results show that local, targeted ablation is possible in the close neighborhood of the electrode, paving the way for the clinical application in the treatment of focal epilepsy.

Folyóirat címe:

SENSORS

Megjelenés éve:

2025

Kötet:

Szám:

ISSN:

1424-8220

Intézmény:

Pázmány Péter Katolikus Egyetem

Kar:

Információs Technológiai és Bionikai Kar (2013.07.-)